Polycations. 19. The synthesis of symmetrical dicationic lipids with internal dimethylazonia functionalities separated by a spacer unit and pendant chains

…, JLI Rizzo, D Montenegro, J Leb, D Coleman…

Index: Engel, Robert; Rizzo, JaimeLee Iolani; Montenegro, Diego; Leb, Jay; Coleman, Delroy; Hong, Carolyn; Jeanty, Herby; Thomas, Marie Chemistry and Physics of Lipids, 2009 , vol. 160, # 2 p. 105 - 108

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Abstract

Herein is reported the preparation of several series of symmetrical polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on several series of parent diamines where dimethylazonia functionalities are present, separated by a central structural unit, and pendant terminal chains. The resultant materials are of significant interest for a variety of purposes, such as serving as antihydrophobic species and as transfectins, ...