Looking glass mechanism-based inhibition of peptidylglycine α-amidating monooxygenase

MS Foster, CD Oldham, SW May

Index: Foster, Michael S.; Oldham, Charlie D.; May, Sheldon W. Tetrahedron Asymmetry, 2011 , vol. 22, # 3 p. 283 - 293

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Citation Number: 3

Abstract

Carboxyl-terminal amidation, a required post-translational modification for the bioactivation of many peptide hormones, entails sequential enzymatic action by peptidylglycine α- monooxygenase (PAM, EC 1.14. 17.3) and peptidylamidoglycolate lyase (PGL, EC 4.3. 2.5). We have previously demonstrated that PAM and PGL exhibit strict tandem reaction stereospecificities, with PAM producing exclusively α-hydroxyglycine moieties of absolute ...