Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5 …
…, A Negi, A Samali, E Szegezdi, PV Murphy
Index: Matos, Marie-Christine; Murphy, Paul V. Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1803 - 1806
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Abstract
A build–couple–pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis
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