Synthesis and In??Vitro Antimycobacterial Activity of Fluoroquinolone Derivatives Containing a Coumarin Moiety
…, LS Feng, K Lv, Y Guan, HY Guo, CL Xiao
Index: Guo, Qiang; Liu, Ming-Liang; Feng, Lian-Shun; Lv, Kai; Guan, Yan; Guo, Hui-Yuan; Xiao, Chun-Ling Archiv der Pharmazie, 2011 , vol. 344, # 12 p. 802 - 809
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Citation Number: 10
Abstract
Abstract A series of gatifloxacin, ciprofloxacin, and 8-OCH 3 ciprofloxacin coumarin derivatives with remarkable improvement in lipophilicity as compared to the parent fluoroquinolones was designed, synthesized, and characterized by 1 H-NMR, MS, and HRMS. These derivatives were evaluated for their in-vitro activity against Mycobacterium smegmatis CMCC 93202 and MTB H37Rv ATCC 27294. All of the synthesized ...
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