N-Phenyl-N'-pyridinylureas as anticonvulsant agents

…, CP Taylor, FM Hershenson, DL Miskell

Index: Pavia; Lobbestael; Taylor; Hershenson; Miskell Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 854 - 861

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Citation Number: 55

Abstract

A series of N-phenyl-N'-pyridinylureas wae. examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2, 6disubstituted-phenyl)- N'-(4-pyridinyl) urea series, with 37 exhibiting the best overall anticonvulsant profile. Compound 37 was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The ...