Evaluation and Optimisation of the Reagent Addition Sequence during the Synthesis of Atrazine (6-Chloro-N 2-ethyl-N 4-isopropyl-1, 3, 5-triazine-2, 4-diamine) Using …

B Barton, S Gouws, MC Schaefer…

Index: Organic Process Research and Development, , vol. 7, # 6 p. 1071 - 1076

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Citation Number: 9

Abstract

... is first reacted with 2 to reduce the occurrence of disubstitution of the organic substrate. ... After completing the second step of the process, carried out with the same sequence of addition ... for the concurrent addition of IPA followed by base (NaOH) (step 1 of the synthetic procedure). ...