Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

…, ZJ Liu, X Zhai, DD Ge, Q Huang, P Gong

Index: Zhao, Yan-Fang; Liu, Zi-Jian; Zhai, Xin; Ge, Dan-Dan; Huang, Qiang; Gong, Ping Chinese Chemical Letters, 2013 , vol. 24, # 5 p. 386 - 388

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Citation Number: 6

Abstract

A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl) pyrimidine-4-yl] piperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 ...