Synthesis

Pyrroles and Indolizidines from Deprotonated α-(Alkylideneamino) nitriles

I Schäfer, T Opatz

Index: Schaefer, Ines; Opatz, Till Synthesis, 2011 , # 11 p. 1691 - 1704

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Abstract

Abstract Their ready availability from simple starting materials in only two synthetic steps and their versatility as building blocks for the construction of highly substituted amines and N- heterocycles renders α-(alkylideneamino) nitriles useful synthetic intermediates. Herein, short syntheses of tri-and tetrasubstituted pyrroles including the northern half of the HMG- CoA reductase inhibitor atorvastatin as well as an access to 3-substituted indolizidines will ...