5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analog

H Griengl, M Bodenteich, W Hayden…

Index: Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684

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Citation Number: 80

Abstract

Met hod M. Anhydro-2-phenyl-3-hydroxyoxazolo [3, 2-a 1-pyridinium Hydroxide (39). A rapidly stirred solution of mandelic acid (7.6 g, 0.05 mol) in DMF (50 mL) was treated portionwise with NaH (5.1 g of 50% dispersion in mineral oil, 0.105 mol). When the evolution of hydrogen was complete, 2-bromopyridine (11.9 g, 0.075 mol) was added and the mixture heated at 90 “C for 6 h. Addition of Et20 to the cooled mixture gave a white solid that was ...