Tetrahedron Letters

Synthesis of a novel diarylheptanoid isolated from Zingiber officinale

GD Parker, PT Seden, CL Willis

Index: Parker, Gregory D.; Seden, Peter T.; Willis, Christine L. Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3686 - 3689

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Citation Number: 4

Abstract

Syntheses of 4-acetoxy-2, 6-disubstituted tetrahydropyrans via Prins cyclisation of homoallylic alcohols with benzylic aldehydes are described and the methodology is applied in the total synthesis of diarylheptanoid 1 confirming both the structure and absolute configuration of the natural product.