Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton

…, T Okamura, T Sato, T Dairi, T Hoshino

Index: Nakano, Chiaki; Okamura, Tomoo; Sato, Tsutomu; Dairi, Tohru; Hoshino, Tsutomu Chemical Communications, 2005 , # 8 p. 1016 - 1018

Full Text: HTML

Citation Number: 38

Abstract

The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5 (6), 13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate.

Related Articles:

Biosynthetic gene-based secondary metabolite screening: a new diterpene, methyl phomopsenonate, from the fungus Phomopsis amygdali

[Toyomasu, Tomonobu; Kaneko, Akane; Tokiwano, Tetsuo; Kanno, Yuya; Kanno, Yuri; Niida, Rie; Miura, Shigeyoshi; Nishioka, Taiki; Ikeda, Chiho; Mitsuhashi, Wataru; Dairi, Tohru; Kawano, Tomikazu; Oikawa, Hideaki; Kato, Nobuo; Sassa, Takeshi Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1541 - 1548]

Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce ( …

[Schmidt, Axel; Gershenzon, Jonathan Phytochemistry, 2007 , vol. 68, # 21 p. 2649 - 2659]

More Articles...