Concise and highly efficient approach to three key pyrimidine precursors for rosuvastatin synthesis
D Šterk, Z Časar, M Jukič, J Košmrlj
Index: Sterk, Damjan; Casar, Zdenko; Jukic, Marko; Kosmrlj, Janez Tetrahedron, 2012 , vol. 68, # 9 p. 2155 - 2160
Full Text: HTML
Citation Number: 18
Abstract
We report the synthesis of 5-formyl-, 5-(hydroxymethyl)-, and 5-(bromomethyl) substituted N- [4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide. The presented synthetic approach is based on highly efficient three step preparation of functionalized 5- methylpyrimidine. The methyl group is selectively brominated by NBS with irradiation into the bromomethyl derivative, which is then transformed into the hydroxymethyl or formyl ...
Related Articles:
[Bouziane, Asmae; Carboni, Bertrand; Bruneau, Christian; Carreaux, Francois; Renaud, Jean-Luc Tetrahedron, 2008 , vol. 64, # 51 p. 11745 - 11750]
DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones
[Li, Yang; Xue, Dong; Lu, Wei; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Organic Letters, 2014 , vol. 16, # 1 p. 66 - 69]
Catalytic asymmetric conjugate allylation of coumarins
[Chang, Lu; Kuang, Yulong; Qin, Bo; Zhou, Xin; Liu, Xiaohua; Lin, Lili; Feng, Xiaoming Organic Letters, 2010 , vol. 12, # 10 p. 2214 - 2217]
[Cadierno, Victorio; Crochet, Pascale; Francos, Javier; Garcia-Garrido, Sergio E.; Gimeno, Jose; Nebra, Noel Green Chemistry, 2009 , vol. 11, # 12 p. 1992 - 2000]
[Lagoja, Irene; Pannecouque, Christophe; Griffioen, Gerard; Wera, Stefaan; Rojasdelaparra, Veronica Maria; Van Aerschot, Arthur European Journal of Pharmaceutical Sciences, 2011 , vol. 43, # 5 p. 386 - 392]