Journal of medicinal chemistry

Pyridoxal phosphate. II. Benzene analogs. 2-Formylphenoxyacetic acids as potential antimetabolites of pyridoxal phosphate

TL Hullar, DL Failla

Index: Hullar,T.L.; Failla,D.L. Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 420 - 424

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Citation Number: 18

Abstract

() liv: ti~ tl: uid Siiell reportedd that a pyridoxal phos-1) h: it e (l'1> aL4 1) dependent enzyme, alanine racemase from Stt, epiococcus jaecalis, could be inhibited competitively by 4- nitrosalicylaldehyde (2a), presumably because 2a c: ui: idequ: ttely simu1: tte I'd.) To use this ohvrvatioii: ii the basiy for: I general series of simple~ iotihc~ tc~ i~ ocyclic, 1'Pal-specific eiizynie inhibitors, sonie 4-and. j-. ribstituted salicylaldehgdes (2) were syii-tlicwzed arid ...