Tetrahedron Letters

Synthesis of 3-aryl substituted benzo [1, 2, 5] triazepin-4-ones via intramolecular imine formation

MJ Tomaszewski, L Boisvert, S Jin

Index: Tomaszewski, Miroslaw J.; Boisvert, Luc; Jin, Shujuan Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1435 - 1437

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Citation Number: 8

Abstract

3-Aryl substituted benzo [1, 2, 5] triazepin-4-ones and their pyrido counterparts have been synthesized in five steps from commercially available starting materials. The key step involves base-induced cleavage of trifluoroacetyl-protected hydrazine intermediates and in situ intramolecular imine formation.