The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS

…, D Xu, QL Guo, J Shang, JW Chern, ML Chen

Index: Cao, Xin; You, Qi-Dong; Li, Zhi-Yu; Liu, Xiao-Rong; Xu, Dan; Guo, Qing-Long; Shang, Jing; Chern, Ji-Wang; Chen, Meng-Ling Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6206 - 6209

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Citation Number: 10

Abstract

Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heterocycle amine-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, synthesized and evaluated as multiple targets agents in cancer therapy. All compounds were evaluated by two related enzyme inhibition assays and an anti- proliferation assay in vitro. The results showed that most compounds inhibited c-Src and ...

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