Synthesis of (S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles
H Josien, DP Curran
Index: Josien, Hubert; Curran, Dennis P. Tetrahedron, 1997 , vol. 53, # 26 p. 8881 - 8886
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Citation Number: 79
Abstract
(S)-Mappicine (2) and mappicine ketone (1) have been prepared from methylacetoacetate (4) by a strategy featuring a radical cascade reaction of an isonitrile as the key step. The introduction of the hydroxy group of (S)-mappicine occurred with moderate selectivity through asymmetric hydroxylation.
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