Synthesis of 2'(3')-phosphates and 2'(3')-phosphorothioates of 5'-O-carboxymethylinosine and related compounds

A Holý, P Kois

Index: Holy, Antonin; Kois, Pavol Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 10 p. 2817 - 2829

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Citation Number: 7

Abstract

Abstract 5'-O-Carboxymethylinosine (IX) was prepared from disodium salt of 2', 3'-O- isopropylideneinosine (VIII) by treatment with sodium chloroacetate, followed by acid hydrolysis. 5'-O-(2-Aminoethylamidocarbonylmethyl) inosine (XIII) was obtained by reaction of IX with p-nitrophenol and subsequent treatment with ethylenediamine. Action of triethyl phosphite on the compounds IX and XIII afforded the corresponding 5'-O-substituted 2'(3')- ...