Tetrahedron Letters

Oxidation of 9-β-d-ribofuranosyl uric acid by one-electron oxidants versus singlet oxygen and its implications for the oxidation of 8-oxo-7, 8-dihydroguanosine

KV Nguyen, JG Muller, CJ Burrows

Index: Nguyen, Khiem V.; Muller, James G.; Burrows, Cynthia J. Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2176 - 2180

Full Text: HTML

Citation Number: 6

Abstract

Uric acid, a cellular antioxidant, undergoes oxidation in the presence of one-electron oxidants as well as singlet oxygen. In the present work, the oxidation pathways and products formed from oxidation of the uric acid nucleoside are compared to the more commonly studied uric acid free base. A wider distribution of products, including allantoin, urea, caffolide, and 5-carboxamido-5-hydroxyhydantoin nucleosides, are formed when the N9 ...