Synthesis and properties of deoxyoligonucleotides containing putrescinylthymine (nucleosides and nucleotides. LXXVI).
T TAKEDA, K IKEDA, Y MIZUNO, T UEDA
Index: Takeda; Ikeda; Mizuno; Ueda Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 9 p. 3558 - 3567
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Citation Number: 32
Abstract
Putrescinylthymidine was prepared by the reduction of the Schiff base formed from a 2'- deoxy-5-formyluridine derivative and N-phthaloylputrescine, followed by deprotection. The following deoxyoligonucleotides containing putrescinylthymine (TP) were synthesized; dodecathymidylic acids containing two to four TP residues, self-complementary decanucleotides (AAGAATTCTT) and dodecanucleotides (AGATAGCTATCT) in which T ...
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