Highly polar potential metabolites of the neuroleptic agent oxyprothepin: Synthesis of 2-hydroxy-8-methylsulfonyl and 3-hydroxy-8-methylsulfonyl derivatives of 10-[4-( …
J Jílek, J Holubek, E Svátek, J Schlanger…
Index: Jilek; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 2 p. 519 - 537
Full Text: HTML
Citation Number: 2
Abstract
Abstract The acid XI, obtained by reaction of (2-iodo-5-methoxyphenyl) acetic acid with 4- (methylsulfonyl) thiophenol (VIII) in dimethylformamide in the presence of potassium carbonate and copper, was transformed via intermediates XIIa-XIVa to compound XVa. Demethylation with boron tribromide afforded compound III, the potential metabolite of oxyprothepin (II). Its oxidation with hydrogen peroxide in acetic acid gave the sulfoxide ...
Related Articles:
Supramolecular Arrangement of Molybdenum Carbonyl Metallosurfactants with CO-Releasing Properties
[Chakravarthy, Rajan Deepan; Ramkumar, Venkatachalam; Chand, Dillip Kumar Green Chemistry, 2014 , vol. 16, # 4 p. 2190 - 2196]
Notiz zur Synthese von Alkyl??, Cycloalkyl??und Aryl??(4??aminophenyl)??sulfonen
[Helvetica Chimica Acta, , vol. 66, # 4 p. 1046 - 1052]
[Tetrahedron, , vol. 65, # 10 p. 1951 - 1956]
A novel method for the synthesis of aryl sulfones
[Steensma, Ruo W.; Galabi, Sharen; Tagat, Jayaram R.; McCombie, Stuart W. Tetrahedron Letters, 2001 , vol. 42, # 12 p. 2281 - 2283]
[Collection of Czechoslovak Chemical Communications, , vol. 50, # 2 p. 519 - 537]