Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors

HA Bhuva, SG Kini

Index: Bhuva, Hemal A.; Kini, Suvarna G. Journal of Molecular Graphics and Modelling, 2010 , vol. 29, # 1 p. 32 - 37

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Citation Number: 51

Abstract

Protein tyrosine kinases occupy a central position in the control of cellular proliferation and its inactivation might lead to the discovery of a new generation anticancer compounds. Substituted benzothiazoles have been found to mimic the ATP-competitive binding of genistein and quercetin to tyrosine kinase. A series of novel 2-phenyl-1, 3-benzothiazoles were synthesized and characterised by IR, 1H NMR and mass spectroscopy. All the ...