Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins

IH Kim, KD Combrink, Z Ma, K Chapo, D Yan…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1181 - 1184

Full Text: HTML

Citation Number: 16

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Hence other medicinal chemistry strategies may be necessary to develop novel rifamycin agents that circumvent the rapid resistance ... and in hard-to-treat settings like biofilm-associated infections of indwelling medical devices mediated ...