Antiprion activity of functionalized 9-aminoacridines related to quinacrine

HTN Thi, CY Lee, K Teruya, WY Ong, K Doh-ura…

Index: Nguyen Thi, Hanh Thuy; Lee, Chong-Yew; Teruya, Kenta; Ong, Wei-Yi; Doh-ura, Katsumi; Go, Mei-Lin Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6737 - 6746

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Citation Number: 28

Abstract

A library of functionalized 6-chloro-2-methoxy-(N9-substituted) acridin-9-amines structurally related to quinacrine were synthesized and evaluated for antiprion activity on four different cell models persistently infected with scrapie prion strains (ScN2a, N167, Ch2) or a human disease prion strain (F3). Most of the compounds were distinguished by the side chain attached to 9-amino of the acridine ring. These were dialkylaminoalkyl and phenyl with ...