Synthesis and in vitro antibacterial activity of some 1??(difluoromethoxyphenyl) quinolone??3??carboxylic acids

…, R Krishnan, YI Lin, EF Santos, NA Kuck…

Index: Xiao; Krishnan; Lin; Delos Santos; Kuck; Babine; Lang Jr. Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 7 p. 585 - 588

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Citation Number: 10

Abstract

Abstract 0 We report on the synthesis of N1-phenylquinolones in which the difluoromethoxy rnoiety is utilized as a halogen replacement. The antibacterlial activity is discussed with reference to Nl- halophenylquinolones. _ _ ~ _ _ ... In a previous communication,l we reported the use of the difluoromethoxy moiety as a potential replacement for the halogen in the 6-position of' the third generation quinolone- 3-carboxylic acids. In that study, we attribute the lack of ...