A Novel Solution??and Solid??Phase Approach to 2, 4, 5??tri??and 2, 4, 5, 6??tetrasubstituted pyrimidines and their conversion into condensed heterocycles
T Masquelin, D Sprenger, R Baer, F Gerber…
Index: Masquelin, Thierry; Sprenger, Daniel; Baer, Roman; Gerber, Fernand; Mercadal, Yves Helvetica Chimica Acta, 1998 , vol. 81, # 4 p. 646 - 660
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Citation Number: 49
Abstract
Abstract A novel general synthesis of 2, 4, 5-tri-and 2, 4, 5, 6-tetrasubstituted pyrimidines 5a– d and 7a, e, f, g by condensation of thiouronium salts of type 3 with (ethoxymethylidene) malononitrile (4) and [bis (methylthio) methylidene] malononitrile (6), respectively, was first established in solution (Scheme 1) and successfully transferred onto solid support by using the polymer-bound thiouronium salt 11 (Scheme 3). Further investigations were directed ...