Journal of fluorine chemistry

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives

K Umezu, F Tabuchi, Y Kimura

Index: Umezu, Kazuto; Tabuchi, Fumiya; Kimura, Yoshikazu Journal of Fluorine Chemistry, 2003 , vol. 121, # 1 p. 97 - 99

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Citation Number: 7

Abstract

Ortho-substituted fluorine in 2, 4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1, 3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substituted benzoic acid derivatives were effectively transformed to the corresponding salicylic acid derivatives under the similar conditions.