Organic & biomolecular chemistry

7-N, 7′-N′-(1 ″, 2 ″-Dithianyl-3 ″, 6 ″-dimethylenyl) bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin

SH Lee, H Kohn

Index: Lee, Sang Hyup; Kohn, Harold Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 471 - 482

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Citation Number: 13

Abstract

Dimeric alkylating agents that modify complementary DNA strands have engendered significant interest. We have prepared the novel dimeric mitomycin, 7-N, 7′-N′-(1 ″, 2 ″- dithianyl-3 ″, 6 ″-dimethylenyl) bismitomycin C (9), in which the mitomycins are bridged by