Development of resin-to-resin transfer reactions (RRTR) using Sonogashira chemistry
J Tulla-Puche, G Barany
Index: Tulla-Puche, Judit; Barany, George Tetrahedron, 2005 , vol. 61, # 8 p. 2195 - 2201
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Citation Number: 15
Abstract
Sonogashira chemistry can be used according to the 'resin-to-resin transfer reaction'(RRTR) concept. Two fragments, one containing the halide moiety and the second one incorporating the alkyne functionality, are anchored on different solid supports using allyl and/or Wang- type linkages. Treatment with Pd (0) cleaves the allyl-linked fragment (s) which subsequently undergo Sonogashira coupling under the same conditions.
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