Synthesis of phosphonate and thiophosphonate esters and amides from hydrogen-phosphinates by a novel one-pot activation-coupling-oxidation procedure

…, H Fan, YH Liu, FR Fronczek, RP Hammer

Index: De Fatima Fernandez; Vlaar; Fan; Liu; Fronczek; Hammer Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7390 - 7391

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Citation Number: 30

Abstract

Phosphonates and their derivatives are important analogs of nucleic acids, l peptides, 2 lipids: other biologically important phosphates: and as haptens for preparation of catalytic antib~ dies.~ Currently, phosphonate esters (1, X= 0, Y= 0, Z= 0) and phosphonamidates (1, X= NR, Y= 0, Z= 0) are generally formed by first activating a phosphonate monoester to the phosphonochloridate with thionyl chloride2 or oxalyl chloride: followed by coupling of the ...