Exploring Nitrostyrene as a Scaffold for a New Class a of Monoamine Oxidase Inhibitors

J Reis, C Oliveira, N Milhazes, D Vina…

Index: Reis, Joana; Oliveira, Catarina; Milhazes, Nuno; Vina, Dolores; Borges, Fernanda Letters in Drug Design and Discovery, 2012 , vol. 9, # 10 p. 958 - 961

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Abstract

With the ultimate purpose of finding out the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a β-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. In the present work, we report the synthesis and the pharmacological evaluation of a series of functionalized derivatives of β-methyl-β-nitrostyrene with distinct substitution ...