Synthesis and conformational analysis of 1, 3, 2-diazaphosphorino [6, 1-a] isoquinolines, a new ring system
Z Zalán, TA Martinek, L Lázár, F Fülöp
Index: Zalan, Zita; Martinek, Tamas A.; Lazar, Laszlo; Fueloep, Ferenc Tetrahedron, 2003 , vol. 59, # 46 p. 9117 - 9125
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Citation Number: 37
Abstract
Through ring-closure reactions of N-or 1′-substituted 1-(2′-aminoethyl)-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines (5a-e) with phenylphosphonyl dichloride, 1-or 3-substituted 4- phenyl-1, 3, 4, 6, 7, 11b-tetrahydro-2H-1, 3, 2-diazaphosphorino [6, 1-a] isoquinolin-4-one diastereomers (7a–e and 8a–c, e), the first representatives of a new ring system, were prepared. The diastereomeric ratios in the cyclizations and the conformer (A–E) ...
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