Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling
M Artico, R Di Santo, R Costi, E Novellino…
Index: Journal of Medicinal Chemistry, , vol. 41, # 21 p. 3948 - 3960
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Citation Number: 168
Abstract
... Journal of Medicinal ... Notable exceptions are l-chicoric acid and some dicaffeoylquinic acids isolated from Bolivian medicinal plants which, in addition to being very potent and specific IN inhibitors in enzyme assays, inhibit the HIV-1 multiplication in acutely infected ... Chemistry. ...
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