Practical and general method for the direct synthesis of alkyl fluorides from alcohols under mild conditions: a reinvestigation

M Rupprich, C Decristoforo, B Matuszczak

Index: Rupprich, Marco; Decristoforo, Clemens; Matuszczak, Barbara Monatshefte fur Chemie, 2009 , vol. 140, # 4 p. 405 - 407

Full Text: HTML

Citation Number: 2

Abstract

Recently, Bandgar et al. [2] published a convenient, mild and general method for the direct conversion of alcohols into the corresponding alkyl fluorides in very good yields. This procedure is characterized by the treatment of alcohols with triphenylphosphine (Ph 3 P) and potassium fluoride in carbon tetrachloride/DMF at room temperature (Scheme 1). Similar conditions have already been described in the literature for the preparation of alkyl fluorides. However, these reactions were ...