Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole

…, ALP de Miranda, CAM Fraga, EJ Barreiro

Index: Lima, Patricia C.; Lima, Lidia M.; Da Silva, Kelli Cristine M.; Leda, Paulo Henrique O.; De Miranda, Ana Luisa P.; Fraga, Carlos A. M.; Barreiro, Eliezer J. European Journal of Medicinal Chemistry, 2000 , vol. 35, # 2 p. 187 - 203

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Citation Number: 193

Abstract

Anew series of antinociceptive compounds belonging to the N-acylarylhydrazone (NAH) class were synthesized from natural safrole (7). The most analgesic derivative represented by 10f,[(4'-N, N-dimethylaminobenzylidene-3-(3', 4'-methylenedioxyphenyl) propionylhydrazine], was more potent than dipyrone and indomethacin, used as standards. The NAH compounds described herein were structurally planned by molecular ...