Organic letters

Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin,(-)-matairesinol, and related natural products

J Fischer, AJ Reynolds, LA Sharp, MS Sherburn

Index: Fischer, Joshua; Reynolds, Aaron J.; Sharp, Lisa A.; Sherburn, Michael S. Organic Letters, 2004 , vol. 6, # 9 p. 1345 - 1348

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Citation Number: 62

Abstract

Total syntheses of seven biologically important lignan natural products, including (-)- arctigenin,(-)-matairesinol, and (-)-α-conidendrin, by way of a highly stereoselective domino radical sequence is presented. The reported stereochemistry of the natural product 7- hydroxyarctigenin is shown to be erroneous; a diastereoisomeric structure is assigned to the natural product.