Synthesis and IR/MS Study of 3, 5-Dimethyladamantanamine Hydrochloride Salt

H Ren, H Ying, P Ouyang, J Lin…

Index: Ren, Huixue; Ying, Hanjie; Ouyang, Pingkai; Lin, Jimao; Jing, Liu Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5107 - 5110

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Abstract

Abstract This paper studied the synthesis of memantine hydrochloride characteristics by optimizing the synthetic route in the bromination of acid hydrolysis under the conditions of acetonitrile and the final salt formation reaction, so that memantine hydrochloride in an overall yield of the products from the 67.3% reported in the literature increased to 81.5%. Compared to 1, 3-dimethyl adamantane and 3, 5-dimethyl-adamantanamine, the infrared ...