2H-benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted …
JC Hazelton, B Iddon, H Suschitzky, LH Woolley
Index: Hazelton; Iddon; Suschitzky; Woolley Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794
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Citation Number: 41
Abstract
Polysubstiluted o-phenylenediamines were syathesised in moderate to high yield by reductive cleavage of the corresponding 2H-benzimidazole-2-spirocyclohexane with sodium dithionite in aqueous ethanol and converted into methyl benzimidazole-2-carbamates and 2- methylthio-and 2-trifluoromethylbenzimidazoles with known or potential anthelminthic activity. 5-(Pyrimidin-2-ylthio)-benzimidazole and 1 l-(pyridin-2-ylthio) dioenzo [a, c] ...
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