NO-SSRIs: nitric oxide chimera drugs incorporating a selective serotonin reuptake inhibitor

…, E Tavassoli, B Michalsen, RT Asghodom…

Index: Abdul-Hay, Samer; Schiefer, Isaac T.; Chandrasena, R. Esala P.; Li, Min; Abdelhamid, Ramy; Wang, Yue-Ting; Tavassoli, Ehsan; Michalsen, Bradley; Asghodom, Rezene T.; Luo, Jia; Thatcher, Gregory R. J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 656 - 661

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Citation Number: 11

Abstract

Hybrid nitrate drugs have been reported to provide NO bioactivity to ameliorate side effects or to provide ancillary therapeutic activity. Hybrid nitrate selective serotonin reuptake inhibitors (NO-SSRIs) were prepared to improve the therapeutic profile of this drug class. A synthetic strategy for use of a thiocarbamate linker was developed, which in the case of NO- fluoxetine facilitated hydrolysis to fluoxetine at pH 7.4 within 7 h. In cell culture, NO-SSRIs ...