An alternative procedure for preparation of cefdinir

…, B Tolón, JC Rodrı́guez, H Velez, B Valdés, MA López…

Index: Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Rodriguez, Juan C.; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo Farmaco, 2003 , vol. 58, # 6 p. 409 - 418

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Citation Number: 25

Abstract

Cefdinir, a broad spectrum third-generation cephalosporin for oral administration, was prepared by the following synthetic pathway: synthesis of diphenylmethyl 7β-amino-3-vinyl-3- cephem-4-carboxylate hydrochloride from 7-aminocephalosporanic acid (7-ACA), preparation of sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino) acetate from ethyl acetoacetate, coupling of both intermediaries to obtain diphenylmethyl 7β-[2-(2- ...