Synthesis of boc-amino tetrazoles derived from α-amino acids

VV Sureshbabu, SA Naik…

Index: Sureshbabu, Vommina V.; Naik, Shankar A.; Nagendra Synthetic Communications, 2009 , vol. 39, # 3 p. 395 - 406

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Citation Number: 15

Abstract

Abstract A simple route for the synthesis of Boc-protected tetrazole analogs of amino acids starting from N α-Boc amino acids has been described. The [2+ 3] cycloaddition of Boc-α- amino nitrile and sodium azide in the presence of a catalytic amount of zinc bromide yielded the desired tetrazoles in good yields and purity. All the compounds obtained have been characterized by 1H and 13C-NMR and mass spectral studies.