Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor

AT Gillmore, M Badland, CL Crook…

Index: Organic Process Research and Development, , vol. 16, # 12 p. 1897 - 1904

Full Text: HTML

Citation Number: 8

Abstract

... Organic Process Research & Development. ... salt ((S)-CSA) was selected for tablet formulation which meant that a new API crystallization procedure was required ... allow us to address the scale-up issues observed during the reduction of nitroalkene 6. Routine process safety testing ...

Related Articles:

Solvent-mediated one-pot synthesis of cyclic N-substituted imides

[Organic Preparations and Procedures International, , vol. 45, # 4 p. 314 - 320]

Photochemistry of N-phthaloyl derivatives of electron-donor-substituted amino acids

[Tetrahedron, , vol. 50, # 3 p. 701 - 714]

Synthesis of mandelic acid derived phthalimides as a new class of anti-inflammatory and antimicrobial agents

[Varala, Ravi; Kotra, Vijay; Alam, M. Mujahid; Kumar, N. Ramesh; Ganapaty; Adapa, Srinivas R. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 8 p. 1243 - 1248]

Exploratory studies probing the intermediacy of azomethine ylides in the photochemistry of N-phthaloyl derivatives of α-amino acids and β-amino alcohols

[Tetrahedron, , vol. 55, # 41 p. 11997 - 12008]

A procedure for preparing N-hydroxyethyl-substituted succinimide and phthalimide

[Gasanov; Allakhverdiev Russian Journal of Applied Chemistry, 2004 , vol. 77, # 12 p. 2034 - 2035]

More Articles...