A new approach to bicyclomycin
…, JA Gregory, RB Herbert, PG Sammes
Index: Dawson, Ian M.; Gregory, Julian A.; Herbert, Richard B.; Sammes, Peter G. Journal of the Chemical Society, Chemical Communications, 1986 , # 8 p. 620 - 621
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Citation Number: 5
Abstract
A simple route to the bicyclomycin nucleus (2) is described which involves use of a P-vinyl sulphone as a new vinylic cation synthon. ... Bicyclomycin (1), which is currently used as an antibiotic in animal foodstuff,l has been the subject of several recent synthetic studies.2.3 Herein we describe an alternative, novel and short synthesis of the key intermediate (2), which has been used in the total synthesis of bicyclomycin.3 Retrosynthetic analysis of the structure of the ...
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