Bioorganic & medicinal chemistry letters

Reaction of thiols with 7-methylbenzopentathiepin

T Chatterji, KS Gates

Index: Chatterji, Tonika; Gates, Kent S. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1349 - 1352

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Citation Number: 45

Abstract

Polysulfides typically react readily with thiols, thus, reactions of endogenous cellular thiols with the polysulfide linkage in naturally-occuring pentathiepin cytotoxins are likely to be an important aspect of their biological chemistry. Here, it is reported that the reaction of thiols with the pentathiepin ring system initially produces a complex mixture of polysulfides that further decomposes in the presence of excess thiol to yield the corresponding 1, 2- ...