The Journal of organic chemistry

Preparation of tertiary alkyl carbinamines, propargylamines, and α-heteroarylamines by ketone-based aminoalkylation

AR Katritzky, H Yang, SK Singh

Index: Klein, Jean-Louis; Combret, Jean-Claude Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 1-2 p. 28 - 32

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Citation Number: 15

Abstract

... Volume: Page: ... and a secondary amine to generate a β-amino carbonyl compound (Mannich base) (Scheme 1). The classical Mannich reaction, although it soon became a key for the synthesis of pharmaceuticals and natural products, 2 was restricted to ...

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