Structure–activity relationship of dihydroimidazo-, dihydropyrimido, tetrahydrodiazepino-[2, 1-b]-thiazoles, and-benzothiazoles as an acylation catalyst

…, Y Kosaki, R Sato, M Shiratori, M Shibuno, T Shishido

Index: Okamoto, Sentaro; Sakai, Yuzo; Watanabe, Saki; Nishi, Shohei; Yoneyama, Aya; Katsumata, Hitomi; Kosaki, Yu; Sato, Rumi; Shiratori, Megumi; Shibuno, Misuzu; Shishido, Tsukasa Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1909 - 1912

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Citation Number: 3

Abstract

Abstract Cyclic isothioureas 1, 2, 3, and 4 were synthesized through a four-step procedure from the corresponding ortho-bromoanilines 10 via Pd-or Cu-catalyzed cyclization– benzothiazole formation. Nonbenzo analogues 7, 8, and 9 were synthesized by a condensation reaction of cyclic thioureas 15 and α-bromoacetophenones 14. Investigations of the acylation reactions of 1-phenylethanol with acid anhydrides in the presence of these ...