One-pot preparation of caffeic acid esters from 3, 4-dihydroxybenzaldehyde

…, CN Xia, GH Wang, W Zhou

Index: Hu, Wei-Xiao; Xia, Chun-Nian; Wang, Guo-Hong; Zhou, Wei Journal of Chemical Research, 2006 , # 9 p. 586 - 588

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Citation Number: 5

Abstract

A convenient one-pot process for preparing various esters of caffeic acid from 3, 4- dihydroxybenzaldehyde has been developed. The alcohols or phenols react with Meldrum's acid to form malonic acid mono-esters, which, without separating, immediately react with 3, 4- dihydroxybenzaldehyde to afford the desired esters in good yield. The 1H NMR data and X- ray diffraction analyses indicate that these α, β-unsaturated esters are in trans (E) form in ...