Liquid??Phase RNA Synthesis by Using Alkyl??Chain??Soluble Support
S Kim, M Matsumoto, K Chiba
Index: Kim, Shokaku; Matsumoto, Masanori; Chiba, Kazuhiro Chemistry - A European Journal, 2013 , vol. 19, # 26 p. 8615 - 8620
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Citation Number: 4
Abstract
Abstract Recent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid-phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid-phase synthesis, some issues in the process remain to be addressed, ...
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