Synthesis of β 2-homophenylalanine derivatives by Negishi cross-coupling reactions

HE Bartrum, H Adams, L Caggiano, RFW Jackson

Index: Bartrum, Hannah E.; Adams, Harry; Caggiano, Lorenzo; Jackson, Richard F.W. Tetrahedron, 2008 , vol. 64, # 17 p. 3701 - 3712

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Citation Number: 10

Abstract

Three approaches to the synthesis of β2-homophenylalanine derivatives using Negishi cross-coupling reaction are reported. In the first two approaches, two protected α-iodomethyl- β-amino esters are each converted into the corresponding organozinc iodides, which then undergo Pd-catalysed cross-coupling with aromatic halides to give β2-homophenylalanine derivatives, and the X-ray crystal structure of one product is reported. Alternatively, ...