2-(Aminobenzyl)-1, 2, 3, 4-tetrahydroisoquinolines: a new class of α2-adrenergic receptor antagonists

JF Stambach, I Kanmacher, L Jung, C Schott…

Index: Stambach; Kanmacher; Jung; Schott; Heitz; Stoclet European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 427 - 432

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Citation Number: 4

Abstract

Abstract A new class of α 2-adrenergic receptor antagonists, the 2-(aminobenzyl)-1, 2, 3, 4- tetrahydroisoquinolines 4 and their derivatives, is described. Two synthetic routes are reported. An investigation of the structure-activity relationships including various substitutions of the isoquinoline moiety and the benzyl group is discussed. The affinity and selectivity for both α 1-and α 2-adrenoceptors was defined by studying the displacement of ...