Total Synthesis of (−)??Epothilone A
…, OM Böhm, A Limberg, M Cordes
Index: Schinzer, Dieter; Bauer, Armin; Boehm, Oliver M.; Limberg, Anja; Cordes, Martin Chemistry - A European Journal, 1999 , vol. 5, # 9 p. 2483 - 2491
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Citation Number: 111
Abstract
Abstract Epothilones 1 (1 A: R= H; 1 B: R= Me) as promising, new microtubule-stabilizing natural products with taxol-like biological activity were isolated from myxo bacteria. A flexible and convergent total synthesis of epothilone A (1 A) and two formal total syntheses of epothilone B (1 B) for an easy and facile access to epothilones are reported.
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